Anti-cytoplasmic 5'-nucleotidase is associated with which disease?

Prepare for the CMS II Rheumatology E1 Exam. Enhance your skills with engaging flashcards, detailed explanations, and multiple-choice questions. Get exam-ready today!

Multiple Choice

Anti-cytoplasmic 5'-nucleotidase is associated with which disease?

Explanation:
Anti-cytoplasmic 5'-nucleotidase (NT5C1A) antibodies are a biomarker most closely linked to inclusion body myositis. In practice, a substantial proportion of IBM patients have anti-NT5C1A, while this antibody is uncommon in dermatomyositis, polymyositis, or reactive arthritis. Finding anti-NT5C1A supports IBM in the right clinical and biopsy context, though its absence does not rule out IBM.

Anti-cytoplasmic 5'-nucleotidase (NT5C1A) antibodies are a biomarker most closely linked to inclusion body myositis. In practice, a substantial proportion of IBM patients have anti-NT5C1A, while this antibody is uncommon in dermatomyositis, polymyositis, or reactive arthritis. Finding anti-NT5C1A supports IBM in the right clinical and biopsy context, though its absence does not rule out IBM.

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